2010 Fiscal Year Final Research Report
Exploitation of brain tumor stem cell targeted therapy using neurotransmitters
| Project/Area Number |
20791013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YOSHIKAWA Koichi Yamaguchi University, 大学院・医学系研究科, 助教 (50379955)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳腫瘍 / グリオーマ / 脳腫瘍幹細胞 / 神経作動薬 / ターゲット療法 |
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| Research Abstract |
Brain tumor stem cell (BTSC) play a role of source cell to form and maintain the brain tumor mass. In this study, we successfully established the BTSC cell lines and showed the anti-tumor effect of neurotransmitters as apomorphine, PAPP, ifenprodil, indatraline, sertraline, tegaserod on BTSC. In addition, we showed the anti-tumor effect on BTSC using photodynamic therapy technique using 5-aminolevulinic acid. These results become the cornerstone for development of BTSC target therapy.
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