The efficacy of immunotherapy for mouse brain tumor model

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Nara Medical University
• Principal Investigator: NISHIMURA Fumihiko Nara Medical University, 医学部, 助教 (70433331)
• Project Period (FY): 2008 – 2009
• Keywords: 脳腫瘍 / 免疫治療 / 樹状細胞 / 養子免疫療法 / インターフェロン

Research Abstract

To make a contribution to clinical field, we examined the efficacy of immunotherapy for mouse brain tumor model with adoptive transfer and intratumoral delivery of dendritic cells in this study. First, mice with brain tumor received intratumoral injection of dendritic cells, and then received tumor antigen specific CD8 T cells intravenously. As a result, this combination of the treatment enhanced the homing of adoptive transferred T cells to the brain tumor site, and prolonged the survival time of the treated mice. The reason of this effective treatment was that intratumoral delivered dendritic cells made antigen presentation and induced chemokine production from tumor cells.

Research Products

• [Journal Article] Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development. (2009)
  • Author(s): Matsuda R, Yoshikawa M, Kimura H, Ouji Y, Nakase H, Nishimura F, Nonaka J, Toriumi H, Yamada S, Nishiofuku M, Moriya K, Ishizaka S, Nakamura M, Sakaki T.
  • Journal Title: Cell Transplant. 18(1) Pages: 39-54
• [Journal Article] Treatment of Parkinson's disease model mice with allogeneic embryonic stem cells: necessity of immunosuppressive treatment for sustained improvement. (2009)
  • Author(s): Toriumi H, Yoshikawa M, Matsuda R, Nishimura F, Yamada S, Hirabayashi H, Nakase H, Nonaka J, Ouji Y, Ishizaka S, Sakaki T.
  • Journal Title: Neurol Res. 31(3) Pages: 220-227
• [Journal Article] Case report of intrathecal baclofen administration in a child with severe spasticity attributable to traumatic brain injury. (2009)
  • Author(s): Matsuda R, Nishimura F, Hirabayashi H, Motoyama Y, Mishima H, Park YS, Nakase H, Sakaki T.
  • Journal Title: Brain Nerve. 61(3) Pages: 313-315
• [Journal Article] CoCl(2) inhibits neural differentiation of retinoic acid-treated embryoid bodies. (2008)
  • Author(s): Nonaka J, Yoshikawa M, Ouji Y, Matsuda R, Nishimura F, Yamada S, Nakase H, Moriya K, Nishiofuku M, Ishizaka S, Sakaki T.
  • Journal Title: J Biosci Bioeng. 106(2) Pages: 141-147
• [Presentation] 樹状細胞と養子免疫療法を用いたマウス脳腫瘍モデルに対する治療効果 (2009)
  • Author(s): 西村文彦
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 全日空ゲートタワーホテル大阪
  • Year and Date: 2009-11-08
• [Presentation] サイトカイン産生性樹状細胞と養子免疫療法を用いたマウス脳腫瘍モデルに対する治療効果. (2009)
  • Author(s): 西村文彦
  • Organizer: 第10回日本分子脳神経外科学会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2009-09-20