2009 Fiscal Year Final Research Report
Usefulness of diffusion MRI for assessment of the patients with treated brain tumor
| Project/Area Number |
20791021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
YAMADA Yoshitaka Osaka Medical College, 医学部, 非常勤講師 (00368101)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 拡散強調像 / MRI / 脳腫瘍 / ADC値 / 治療効果判定 |
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| Research Abstract |
Assessment of therapeutic efficiency for malignant glioma patient is traditionally accomplished by measuring changes in tumor size in gadolinium-enhanced T1-weighted MRI at 10 weeks after treatment has been administered. In this study, we evaluated glioblastoma (GB) patients treated by boron neutron capture therapy (BNCT) by using this fDM analysis. The maximum volume of tumor with decrease diffusion by fDM within 7 days was the strongest predictor of patients' survival time since BNCT. The fDM could provide an earlier imaging assessment of the prognosis of GB patients treated by BNCT.
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