Evaluation of a radiosensitizing effect of photosensitizer for malignant gliomas

2011 Fiscal Year Final Research Report

• Project/Area Number: 20791024
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YAMAMOTO Junkoh 産業医科大学, 医学部, 准教授 (80461565)
• Project Period (FY): 2008 – 2011
• Keywords: photodynamic therapy(PDT) / photodynamic diagnosis(PDD) / 放射線治療 / glioma / free radical

Research Abstract

Photosensitizer, such as 5-Aminolevulinic acid(ALA), are used in photodynamic therapy and fluorescence-guided resection of malignant brain tumours due to its high cellular uptake in tumours. In the present study, the possible use of 5-ALA as a radiosensitizer for malignant brain tumours is examined in vitro using rat glioma cell lines(9L, C6). 5-ALA functions as a specific radiosensitizer for malignant gliomas. Intracellular 5-ALA-induced PpIX plays an important role in the production of ROS and the radiosensitizing effect under ionizing irradiation conditions.

Research Products

• [Journal Article] Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro (2012)
  • Author(s): Yamamoto J, et al.
  • Journal Title: Oncol Rep
  • DOI: DOI:10.3892/or.2012.1699.
  • Peer Reviewed
• [Presentation] Evaluation of a radiosensitizing effect of 5-aminolevlunic acid for malignant gliomas (2011)
  • Author(s): Yamamoto J, Saito T, Takahashi M, Nishizawa S
  • Organizer: 13^<th> world congress of the international photodynamic association
  • Place of Presentation: Innsbruck, Austria
  • Year and Date: 20110511-14
• [Presentation] Singlet oxygen detection in PDT (2010)
  • Author(s): Hirano T, Kohno E, Hirakawa K, Yamamoto J, Okazaki S
  • Organizer: The 2^<nd> Asia Japan-Korea-China Joint Symposium of Photodynamic Therapy
  • Place of Presentation: Fukui, Japan
  • Year and Date: 2010-06-12