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2009 Fiscal Year Final Research Report

The molecular imaging study for the mechanism of the Deep brain stimulation in MPTP treated monkey

Research Project

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Project/Area Number 20791025
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

FANG Xin  Hamamatsu University School of Medicine, 分子イメージング先端研究センター, 特任助教 (00469917)

Project Period (FY) 2008 – 2009
Keywords機能脳神経外科学 / パーキンソン氏病 / 脳深部電気刺激術 / 視床下核 / PET / ドパミン受容体 / 脳血流
Research Abstract

To clarify the mechanism of the deep brain stimulation (DBS), we performed the PET study in the MPTP treated monkey by the tracer of H_2^<15>O to measure the regional cerebral blood flow (rCBF). We found the rCBF of medial superior frontal gyrus, supplementary motor cotex, superior parietal lobule and thalamus in the DBS side, the anterior cerebellar cortex in the contralateral side significantly increased, which gave an evidence that the mechanism of STN-DBS lies in the correcting the overactivation of motor controlling network.
In order to clarify the dynamic variation pattern of dopamine transporter (DAT) and D^2 receptor after the dopamine depletion, which greatly influences the efficiency of DBS, we studied the variation of pre-synaptic DA transporter and post-synaptic D^2-like receptor in nigrostriatal DA system using binding assay, behavioral test and a small animal PET. Our data showed that there was a same tendency of the striatal DA transporter decrease both in MFB lesion rats and striatal lesion rats 4 weeks after lesion, however, it showed increase (up-regulation) of D^2-like receptor in the MFB lesion rats, whereas showed decrease (down-regulation) in the striatal lesion rat. This finding strongly indicated the dynamic variation pattern of DAT and D^2 receptor after the dopamine depletion should be taken into account in the molecular imaging study in PD animal models.

  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (2 results) Presentation (6 results)

  • [Journal Article] Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells.2010

    • Author(s)
      Wu YX, Fang X
    • Journal Title

      Planta Med. Feb 76(2)

      Pages: 128-32

  • [Journal Article] Different striatal D2-like receptor function in an early stage after unilateral striatal lesion and medial forebrain bundle lesion in rats2010

    • Author(s)
      Sun W, Sugiyama K, Fang X, Yamaguchi H, Akamine S, Magata Y, Namba H
    • Journal Title

      Brain Res. 1317C

      Pages: 227-235

  • [Presentation] パーキンソンモデルラットの片側線条体破壊モデルと片側MFB破壊モデルの違いーPETによるD2受容体活性の経時的変化測定2010

    • Author(s)
      孫偉, 杉山憲嗣, 方欣, 山口博司, 赤嶺壮一, 間賀田泰寛, 難波宏樹
    • Organizer
      第49回日本定位機能神経外科学会
    • Year and Date
      20100000
  • [Presentation] The dynamic variation of D2 receptor between the unilateral striatal and complete medial forebrain bundle in early and late stage by 6-hydroxydopamine in rats2009

    • Author(s)
      孫偉, 杉山憲嗣, 方欣, 山口博司, 赤嶺壮一, 間賀田泰寛, 難波宏樹
    • Organizer
      日本脳神経外科学会第68回学術総会
    • Year and Date
      20090000
  • [Presentation] H215Oを用いて、MPTPサルにおける脳深部電気刺激下2008

    • Author(s)
      方欣、杉山憲嗣、赤嶺壮一、難波宏樹、宿里充穂、横山ちひろ、水間広、塚田秀夫、尾上浩隆
    • Organizer
      脳血流のPET測定第23回日本大脳基底核研究会
    • Year and Date
      20080000
  • [Presentation] H215O-PET study of motor control network activated by the deep brain stimulation of the subthalamic nucleus in chronic Parkinsonian monkey model2008

    • Author(s)
      Fang X, Sugiyama K, Akamine S, Namba H, Yokoyama C, Shukuri M, Mizuma H, Magata Y, Umemura K, Hokamura K, Yamaguchi H, Tsukada H, Onoe H
    • Organizer
      2008 World Molecular Imaging Congress
    • Year and Date
      20080000
  • [Presentation] The difference of D2 receptor alteration between the unilateral striatal lesion and complete medial forebrain bundle lesion by 6-hydroxydopamine in rats, a PET study2008

    • Author(s)
      Sun W, Fang X, Sugiyama K, Akamine S, Magata Y, Umemura K, Hokamura K, Yamaguchi H, Namba H
    • Organizer
      2008 World Molecular Imaging Congress
    • Year and Date
      20080000
  • [Presentation] パーキンソン氏病ラットモデルに対する分子イメージング研究における共同開発2008

    • Author(s)
      方欣、孫偉、杉山憲嗣、赤嶺壮一、難波宏樹
    • Organizer
      メディカルイノベーションフォーラム
    • Year and Date
      20080000

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Published: 2011-06-18   Modified: 2016-04-21  

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