2009 Fiscal Year Final Research Report
Analysis of interaction between autocrine motility factor and molecules related to bone formation in osteosarcoma cells.
| Project/Area Number |
20791026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gunma University |
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Principal Investigator |
YANAGAWA Takashi Gunma University, 大学院・医学系研究科, 助教 (40400725)
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| Project Period (FY) |
2008 – 2009
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| Keywords | autocrine motility factor / 温熱刺激 / 転移 / 骨形成 / 糖代謝 / FDG-PET |
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| Research Abstract |
Hyperthermia decreased motility of osteosarcoma cells via suppression of autocrine motility factor expression, while did not affect mineralization of osteosarcoma cells. Microarray revealed some subtypes of bone morphogenic protein (BMP) decreased by hyperthermia although others increased, that may compensate bone formation.
AMF is known to be identical to phosphoglucose isomerase that is an essential protein for glycolysis. We revealed metastatic tumor showed higher glucose than primary tumor did, that is compatible with the fact that AMF stimulates tumor motility and metastasis.
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