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2009 Fiscal Year Final Research Report

Therapeutic development of intervertebral disc degeneration targeting proteinase-activated receptor

Research Project

  • PDF
Project/Area Number 20791030
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

AKEDA Koji  Mie University, 医学部・附属病院, 助教 (20422826)

Project Period (FY) 2008 – 2009
Keywords椎間板 / サイトカイン / 蛋白分解酵素 / 細胞外基質 / 椎間板変性
Research Abstract

The results of this study show that intervertebral disc (IVD) cells express PAR-2. The expression of PAR-2 is regulated by IL-1β stimulation. PAR-2 activation accelerates the expression of matrix degrading enzymes. PAR-2 may play an important role in the cytokine-mediated catabolic cascade and consequently may be involved in IVD degeneration.

  • Research Products

    (7 results)

All 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Expression of proteinase-activated receptor-2 in the intervertebral disc.2009

    • Author(s)
      Iida, R., Akeda, K., Kasai, Y., Masuda, K., Morimoto, R., Sakakibara, T., Sato, M., Uchida, A.
    • Journal Title

      Spine (Phila Pa 1976) 34

      Pages: 4

    • Peer Reviewed
  • [Presentation] FUNCTIONAL ANALYSES OF PROTEINASE-ACTIVATED RECEPTOR 2 BY RAT INTERVERTEBRAL DISC CELLS2009

    • Author(s)
      Iida R, Akeda K, Kasai Y, Masuda K, Morimoto R, Iino T, Uchida A
    • Organizer
      55nd Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Las Vegas
    • Year and Date
      20090222-20090225
  • [Presentation] ラット椎間板細胞におけるproteinase-activated receptor-2の機能解析2008

    • Author(s)
      飯田竜、明田浩司、笠井裕一、舛田浩一、内田淳正
    • Organizer
      第23回日本整形外科基礎学術集会
    • Place of Presentation
      浜松市
    • Year and Date
      20081023-20091024
  • [Presentation] ヒト椎間板におけるProtease-Activated Receptor 2の発現-椎間板変性との関連性-2008

    • Author(s)
      明田浩司、飯田竜、笠井裕一、舛田浩一、塩川靖夫、近藤哲士、榊原紀彦、佐藤昌良、内田淳正
    • Organizer
      第37回日本脊椎脊髄病学会
    • Place of Presentation
      東京
    • Year and Date
      20080424-20080426
  • [Presentation] Expression of Proteinase-Activated Receptor 2 on the Human Intervertebral Disc2008

    • Author(s)
      Ryu Iida, Koji Akeda, Yuichi Kasai, Koichi Masuda, Yasuo Shiokawa, Toshihiko Sakakibara, Masayoshi Sato, Takahiro Iino, Atsumasa Uchida
    • Organizer
      54nd Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Year and Date
      20080302-20080305
  • [Presentation] EXPRESSION OF PROTEINASE-ACTIVATED RECEPTOR 2 ON THE HUMAN INTERVERTEBRAL DISC2008

    • Author(s)
      Ryu Iida; Koji Akeda; Yuichi Kasai; Koichi Masuda; Yasuo Shiokawa; Toshihiko Sakakibara; Masayoshi Sato; Takahiro Iino; Atsumasa Uchida
    • Organizer
      The inaugural meeting of the World Forum for Spine Research
    • Place of Presentation
      Kyoto
    • Year and Date
      20080123-20080125
  • [Presentation] 椎間板におけるProteinase-activated receptor 2の発現と機能2008

    • Author(s)
      飯田竜明田浩司、笠井裕一、舛田浩一、森本亮、内田淳正
    • Organizer
      第27回日本運動器移植・再生医学研究会
    • Place of Presentation
      岐阜市
    • Year and Date
      2008-09-27

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Published: 2011-06-18   Modified: 2016-04-21  

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