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2009 Fiscal Year Final Research Report

Analysis of metastatic factors of under coagulation disturbance

Research Project

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Project/Area Number 20791031
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

KUNIHIRO Asanuma  Mie University, 医学部・附属病院, 診療等従事者 (20378285)

Project Period (FY) 2008 – 2009
KeywordsB16 melanoma / 肺転移 / 血液凝固 / 血液凝固抑制マウス / 高肺転移株
Research Abstract

Lung metastases was decreased depend on the inhibition of coagulation activity. Highly lung metastatic cell lines Wa9 and Co9 was successfully made using coagulation inhibited mice and wild mice, respectively. Analysis of expressed genes between Wild, Wa9 and Co9 by DNA array is currently in progress.

  • Research Products

    (6 results)

All 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle puncture model.2009

    • Author(s)
      Seki S. Asanuma-Abe Y, Masuda K, Kawaguchi Y, Asanuma K, Muehleman C, Iwai A, Kimura T.
    • Journal Title

      Arthritis Res Ther. 11(6)

      Pages: R166

    • Peer Reviewed
  • [Journal Article] Spinal neurocutaneous melanosis without cutaneous nevi.2008

    • Author(s)
      Asanuma K, Kasai Y, Takegami K, Ito H, Yoshikawa T, Uchida A.
    • Journal Title

      Spine 1 33(2)

      Pages: E62-5

    • Peer Reviewed
  • [Journal Article] Effect of osteogenic protein-1 on the matrix metaboplism of bovine tendon cells.2008

    • Author(s)
      Yamada M, Akeda K, Asanuma K, Thonar EJ, An HS, Uchida A, Masuda K.
    • Journal Title

      J Orthop Res. 26(1)

      Pages: 42-8

    • Peer Reviewed
  • [Presentation] Thrombin阻害薬‘argatroban'による関節炎の抑制効果の解析2009

    • Author(s)
      淺沼邦洋、吉田格之進、吉川智朗、林辰弥、秋田展幸、岡本貴行、長谷川正裕、須藤啓広、鈴木宏治、内田淳正
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      20091105-20091106
  • [Presentation] The inhibition of coagulation activity by warfarin down-regulates lung metastasis.2009

    • Author(s)
      Kunihiro Asanuma, Nobuyuki Akita, Tatsuya Hayashi, Kakunoshin Yoshida, Takayuki Okamoto, Akihiko Matsumine, Koji Suzuki, Atsumasa Uchida
    • Organizer
      55th Orthopedic Research society
    • Place of Presentation
      Las Vegas Las Vegas, Nevada USA
    • Year and Date
      20090222-20090225
  • [Presentation] トロンビンの椎間板注入による椎間板変性モデル2008

    • Author(s)
      淺沼邦洋、阿部由美子、Rajeawari Pichika, Carol Muehleman、角谷賢一朗、Haward An、内田淳正、舛田浩一
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都市
    • Year and Date
      20081023-20081024

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Published: 2011-06-18   Modified: 2016-04-21  

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