2010 Fiscal Year Final Research Report
Gene therapy in the treatment of ligament injury
| Project/Area Number |
20791040
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
FURUMATSU Takayuki Okayama University, 岡山大学病院, 助教 (20432651)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 靭帯組織再生 / 膝関節靭帯損傷 / 前十字靭帯(ACL) / 内側側副靭帯(MCL) / 遺伝子導入 / Scleraxis / Sox9 |
|---|
| Research Abstract |
In our studies, combined treatment of bFGF, GDF-5, and peptide hydrogels stimulates the healing of rabbit MCL injury model. In addition, bFGF and GDF-5 play important roles in cellular migration and matrix synthesis of ligament-derived cells.
Scleraxis gene transduction using in vivo electroporation and sonoporation enhances the expression of type I collagen gene. Our results suggest that in vivo gene therapy might be a good candidate for the treatment of ligament injury.
|
