2010 Fiscal Year Final Research Report
Development of the treatment of patients with chronic spinal cord injury using operating the cell attachment factors.
| Project/Area Number |
20791045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUZUKI Hidenori Yamaguchi University, 医学部附属病院, 助教 (30393432)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脊髄損傷 / コラーゲンフィラメント / 細胞接着因子 |
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| Research Abstract |
We substituted damaged spinal cord in rats with chronic spinal cord injury for Collagen Filaments (CF). In addition, we impregnated with a Compound A which effected on the cell cycles and stimulated the repairs of tissues. In our vitro study, Compound A acted on the neural cells to promote mature differentiations. However, in vivo study, Compound A effected mainly on the Fibroblasts. So surroundings fibroblasts migrated across to the damaged spinal cord. In results, enough functional recovery were not shown in rats with chronic spinal cord injury. We think that additional ideas were necessary that genetically modified drugs etc effecting on neural cells specificity.
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[Presentation] ラーゲンフィラメント束補填を用いた脊髄再生2009
Author(s)
鈴木秀典, 田口敏彦, 加藤圭彦, 片岡秀雄, 寒竹司, 屋良貴宏, 今釜崇, 吉田佑一郎, 加藤秀豊, 守屋淳詞, 好井覚
Organizer
第38回日本脊椎脊髄病学会
Place of Presentation
神戸市 神戸ポートピアホテル
Year and Date
2009-04-23
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[Presentation] 脊髄損傷ラットに対するコラーゲンフィラメント補填と神経栄養因子補充療法の検討2008
Author(s)
鈴木秀典, 田口敏彦, 加藤圭彦, 片岡秀雄, 寒竹司, 屋良貴宏, 今釜崇, 吉田祐一郎, 加藤秀豊, 守屋淳詞, 好井覚
Organizer
第27回日本運動器移植・再生医学研究会
Place of Presentation
岐阜市 長良川国際会議場
Year and Date
2008-09-27
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