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2009 Fiscal Year Final Research Report

Analysis of IL-27 receptor deficient mouse induced by inflammatory bone destruction model

Research Project

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Project/Area Number 20791055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

FURUKAWA Mitsuru  Keio University, 医学部, 助教 (70468502)

Project Period (FY) 2008 – 2009
Keywordsシグナル伝達 / 免疫学 / 発生・分化
Research Abstract

hIL-27 acts as an anti-inflammatory cytokine in human bone destruction, by inhibiting osteoclastogenesis from hCFU-GMs via STAT1-dependent down-regulation of the transcription factor c-Fos.

  • Research Products

    (9 results)

All 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] IL-27 Abrogates Receptor Activator of NF-kB Ligand-Mediated Osteoclastogenesis of Human.Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos.2009

    • Author(s)
      Furukawa M, Takaishi H, Takito J, Yoda M, Sakai S, Hikata T, Hakozaki A, Uchikawa S, Matsumoto M, Chiba K, Kimura T, Okada Y, Matsuo K, Yoshida H, Toyama Y.
    • Journal Title

      J Immunol 15;183(4)

      Pages: 2397-2406

    • Peer Reviewed
  • [Presentation] IRAK-4 はIL-1 依存性のNF-κB シグナルを介して、骨芽細胞におけるRANKL 発現および破骨細胞の成熟・延命を促進する2009

    • Author(s)
      古川、高石、坂井、東門田、依田、吉田、戸山
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20091105-20091106
  • [Presentation] IRAK-4 はIL-1 依存性のNF-κB シグナルを介して、骨芽細胞におけるRANKL 発現および破骨細胞の成熟・延命を促進する2009

    • Author(s)
      古川、高石、坂井、東門田、依田、吉田、戸山
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      20090723-20090725
  • [Presentation] Foxp3+ Regulatory T cell deficiency induces osteosclerosis via hyperactivation of osteoclast-suppressive2009

    • Author(s)
      Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
    • Organizer
      CD4+T cell subsets ASBMR
    • Place of Presentation
      Colorado Convention Center
    • Year and Date
      2009-09-14
  • [Presentation] IRAK-4 enhances RANKL-mediated osteoclast maturation and survival through via IL-1-dependent NF-kB signaling ASBMR2009

    • Author(s)
      Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
    • Organizer
      Poster Session II on Sunday, September 13, 2009
    • Place of Presentation
      Colorado Convention Center
    • Year and Date
      2009-09-13
  • [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos ASBMR2009

    • Author(s)
      Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
    • Organizer
      Welcome Reception and Plenary Poster Session on Friday
    • Place of Presentation
      Colorado Convention Center
    • Year and Date
      2009-09-11
  • [Presentation] IL-27/WSX-1 シグナルはLPS 刺激によって誘導され、RANKL 依存性の破骨細胞形成をSTAT1 の活性化を介して抑制する2008

    • Author(s)
      古川、高石、坂井、東門田、依田、吉田、戸山
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪(口頭発表)
    • Year and Date
      20081029-20081031
  • [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis from Human Granulocyte-macrophage Colony-forming Unit derived Cells through STAT1-Dependent Inhibition of c-Fos2008

    • Author(s)
      Furukawa,Takaishi,Sakai,Tohmonnda ,Yoda,Toshida
    • Organizer
      ASBMR
    • Place of Presentation
      Canada(Poster presentation)
    • Year and Date
      20080912-20080916
  • [Presentation] IL-27 Abrogates RANKL-mediated Osteoclastogenesis from Human Granulocyte-macrophage Colony-forming Unit derived Cells through STAT1-Dependent Inhibition of c-Fos. Conference2008

    • Author(s)
      Furukawa,Takaishi,Sakai,Tohmonnda, Yoda,Yoshida
    • Organizer
      2nd Osteoimmunology
    • Place of Presentation
      Rhodes in Greece(Oral presentation)
    • Year and Date
      20080608-20080613

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Published: 2011-06-18   Modified: 2016-04-21  

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