2010 Fiscal Year Final Research Report
The preparation of control-released local anesthetics and clinical use for clonic pain therapy.
| Project/Area Number |
20791065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
TOBE Masaru Gunma University, 医学部, 助教 (90400770)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 徐放薬 / 疼痛治療 / 局所麻酔薬 / ポリ乳酸 |
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| Research Abstract |
We created a novel slow-release lidocaine sheet with polylactic-co-glycolic acid. Single sciatic nerve block with slow-release lidocaine inhibited hypersensitivity after paw incision. Spinal cord dorsal horn c-fos expression was consistent with the behavioral results. Slow-release local anesthetics are promising for management of postoperative pain.
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