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2010 Fiscal Year Final Research Report

The preparation of control-released local anesthetics and clinical use for clonic pain therapy.

Research Project

  • PDF
Project/Area Number 20791065
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGunma University

Principal Investigator

TOBE Masaru  Gunma University, 医学部, 助教 (90400770)

Project Period (FY) 2008 – 2010
Keywords徐放薬 / 疼痛治療 / 局所麻酔薬 / ポリ乳酸
Research Abstract

We created a novel slow-release lidocaine sheet with polylactic-co-glycolic acid. Single sciatic nerve block with slow-release lidocaine inhibited hypersensitivity after paw incision. Spinal cord dorsal horn c-fos expression was consistent with the behavioral results. Slow-release local anesthetics are promising for management of postoperative pain.

  • Research Products

    (3 results)

All 2010 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Long-term effect of sciatic nerve with slow-release lidocaine in a rat model of postoperative pain.2010

    • Author(s)
      Masaru Tobe, Hideaki Obata, Takashi Suto, Hideaki Yokoo, Yoichi Nakazato, Yasuhiko Tabata, Shigeru Saito
    • Journal Title

      Anesthesiology 112(6)

      Pages: 1473-1481

    • Peer Reviewed
  • [Presentation] リドカイン徐放薬の毒性と臨床応用への可能性2010

    • Author(s)
      戸部賢
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡国際会議場・マリンメッセ(福岡市)
    • Year and Date
      2010-06-04
  • [Presentation] リドカイン徐放薬の作成と疼痛治療への応用2008

    • Author(s)
      戸部賢
    • Organizer
      第55回日本麻酔科学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2008-06-14

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Published: 2012-02-13   Modified: 2016-04-21  

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