2009 Fiscal Year Final Research Report
Administration of the Rho-kinase inhibitor Fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
| Project/Area Number |
20791079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIBATA Itsuko Nagasaki University, 病院, 助教 (10404245)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 心筋虚血再灌流障害 / 心筋スタニング / Rho-kinase阻害薬 / 薬理学的プレコンディショニング / ポストコンディショニング |
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| Research Abstract |
We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in anesthetized open-chest swine. This cardioprotective effect of fasudil against myocardial stunning was probably not related to systemic or coronary hemodynamic changes. Rho-kinase inhibition during early reperfusion could therefore protect against myocardial stunning.
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