2010 Fiscal Year Final Research Report
Pathosis and control of splanchnic circulation in septic shock
| Project/Area Number |
20791080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SEKINO Motohiro Nagasaki University, 病院, 助教 (40380927)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 敗血症性ショック / 腸管循環カ / ルペリチド |
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| Research Abstract |
In porcine fluid-resuscitated endotoxemia model, a low dose of carperitide, a synthetic atrial natriuretic peptide, administered prior to endotoxemia maintained systemic and splanchnic circulation, and prevented the deterioration of oxygenation. Carperitide infusion is a potentially beneficial therapy with respect to systemic and splanchnic circulation as well as the respiratory system during sepsis.
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