2009 Fiscal Year Final Research Report
The role of VIP in pulmonary hypertension and application for the gene therapy
| Project/Area Number |
20791088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
KAWAKAMI Hiromasa Yokohama City University, 附属病院麻酔科, 助教 (90407958)
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| Project Period (FY) |
2008 – 2009
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| Keywords | VIP / PACAP / PAC1受容体 / 肺高血圧 / プラスミドベクター |
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| Research Abstract |
Pulmonary hypertension (PH) is critical disease. It has been reported that neuropeptides VIP, PACAP involve in pulmonary circulation and respiratory system, however, their functions are not fully elucidated. The contents of VIP and PACAP in the lung decreased in experimental PH, while the expression of their receptors VPAC1, VPAC2 and PAC1 increased. Similar results were obtained from cardiac tissue. To verify the hypothesis that replacement of the peptides may improve PH, we constructed plasmid vector encoding VIP or PACAP. We have been investigating the more efficient method to deliver the plasmid and the effect in PH.
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