The regulatory mechanism of cerebral microvessels and anesthetic effects on micro-circulation in pregnant hypertension.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791091
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: DOJO Mayuko Wakayama Medical University, 医学部, 助教 (90347576)
• Project Period (FY): 2008 – 2010
• Keywords: 妊娠高血圧 / 脳血流 / 麻酔薬

Research Abstract

Pregnancy-induced hypertension is a pivotal complication which is associated with an increased risk of maternal and fetal morbidity and mortality. We hypothesized that failure of the neurovascular coupling via astrocyte is a key mechanism in developing hypertension and cerebrovascular disorders during pregnancy. This study aimed to reveal the regulatory mechanism of cerebral microvessels and anesthetic effects on micro-circulation in pregnant hypertension.