2009 Fiscal Year Final Research Report
Effects of endotoxemia on resistance arteriole : Effects on membrane potential on submucosal small intestine.
| Project/Area Number |
20791098
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
TAKANO Hiromichi Nagoya City University, 大学院・医学研究科, 助教 (70410313)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | ショック |
|---|
| Research Abstract |
The effects of endotoxemia on the diameter change and the membrane potential of submucosal arteriole in guinea pig small intestine were simultaneously measured. The endotoxemia did not significantly change the membrane potential. Acetylcholine (Ach) repolarized and relaxed the vessel in presence of BaCl. Endotoximia inhibited these effects of ACh. The repolarization and vasorelaxation were due to the activation of the two types of the calcium dependent potassium channels. No difference on the role of these channels was observed between the control and the endotiximia model.
|
