2009 Fiscal Year Final Research Report

The analysis and control of the AKT-PI3K signaling pathway in the bladder cancer

Research Project

Project/Area Number	20791100
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Akita University
Principal Investigator	TSURUTA Hiroshi Akita University, 医学部, 助教 (90466590)
Project Period (FY)	2008 – 2009
Keywords	腫瘍学 / 膀胱癌
Research Abstract	We focused on the AKT-PI3K pathway related urinary cytokines which is important to carcinogenesis, progression and metastasis of the bladder cancer. We measured the urinary cytokines using ELISA, and found that mean urinary RANTES level were significantly higher than that of healthy control. Immunohistologically, the expression of CCR5, which is main receptor of RANTES, was found in primary bladder tumors. There was a statistically significant association between increased CCR5 expression in the cytoplasm and tumor stage or tumor grade. The high grade or high stage tumors had significantly higher expression levels of CCR5. Our results suggest that the high level of urine RANTES may be a candidate novel marker of the presence of bladder cancer. Furthermore, the increased CCR5 expression in the cytoplasm of bladder cancer cells may be associated with aggressive type of bladder cancer and be a marker for disease progression.