2009 Fiscal Year Final Research Report
Can doxycycline become new medicine in the last 50 years to reduce renal ischemia reperfusion injury?
| Project/Area Number |
20791111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
ARAKI Motoo Okayama University, 岡山大学病院, 助教 (90467746)
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| Research Collaborator |
KAWAUCHI Keiichiro 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
HIROHATA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90332791)
NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 腎虚血再潅流障害 / ドキシサイクリン / 細胞外マトリックス(MMP) / MMP阻害薬 / 腎移植 |
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| Research Abstract |
We established murine renal ischemia reperfusion injury (IRI) model. Renal hilums of B6 mouse was clumped for 45 minutes under anesthesia. Body temperature was kept on 32℃. We have identified reduced IRI by measuring serum creatinine level and histopathology.
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