2009 Fiscal Year Final Research Report

The study of the relationship between lower urinary outlet symptoms/bladder outlet obstruction and erectile dysfunction

Research Project

Project/Area Number	20791116
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Sapporo Medical University
Principal Investigator	TOSHIAKI Tanaka Sapporo Medical University, 医学部, 研究員 (50398327)
Project Period (FY)	2008 – 2009
Keywords	勃起障害 / 下部尿路通過障害 / 下部尿路症状
Research Abstract	We employed male Sprague-Dawley rats with partial BOO as a LUTS model. Sham-operated animals were used as controls. Voiding and bladder functions of BOO rats were significantly worse than those of sham-operated animals at 4, 8 and 16 weeks after obstruction. Erectile function of BOO rats was significantly decreased compared to sham-operated animals at 16 weeks after obstruction, although it was similar to that of sham-operated animals at 4 and 8 weeks after obstruction. Endothelial nitric oxide synthase mRNA expression was significantly decreased at 16 weeks after obstruction compared to sham-operated animals. We established an animal model for study of the association of LUTS with ED. Endothelial dysfunction induced by impaired eNOS function may be involved in ED following LUTS/BOO.