2009 Fiscal Year Final Research Report
The basic study about kidney differentiation from gene transferred embryonic stem cells
| Project/Area Number |
20791119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
NAKANE Akihiro Nagoya City University, 大学院・医学研究科, 研究員 (70464568)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 再生医療 / 胚性幹細胞 / 遺伝子導入 / 分化実験 / RT-PCR |
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| Research Abstract |
By establishing tetracycline-inducible overexpression in ES cells, our data suggest that Pax2 and additional factors that are induced in the embryoid bodies synergistically upregulate the integrin α 8 and AQP1 that are possibly involved in kidney development. Our method for the generation of tetracycline-inducible ES cell lines will be useful for dissecting the genetic cascades functioning in the early stages of development, as well as for screening candidate genes that direct ES cells toward the desired lineages, which may be applicable to future cell therapies.
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[Presentation] Satisfaction with voiding, appearance, and sexual function in adolescents after hypospadias repair during childhood.2009
Author(s)
Nakane Akihiro, Hayashi Yutaro, Kurokawa Satoshi, Kamisawa Hideyuki, Imura Makoto, Mizuno Kentaro, Kato Toshiki, Kojima Yoshiyuki, Maruyama Tetsuji, Kohri Kenjiro
Organizer
AUA 2009 Annual Meeting
Place of Presentation
Chicago(USA)
Year and Date
20090425-20090430
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