2009 Fiscal Year Final Research Report
Study for biological function in prostate cancer of SND1 and its role for therapeutic target.
| Project/Area Number |
20791124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KIMURA Takahiro Jikei University School of Medicine, 医学部, 助教 (00307430)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 癌 / 泌尿器科 / 前立腺癌 / バイオマーカー |
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| Research Abstract |
The aim of the study was to elucidate the biological function of SND1 in prostate cancer. Transgenic mouse expressed SND1 prostate-specifically was produced and the prostate was observed histologically. At the 18 months old, cancer was not observed in the prostate. To observe the molecular change according to SND1 expression, microarray was performed using total RNA extracted from the prostate. Change of expression was compared between TG and control mice and the change was confirmed by real time PCR. Some molecules were identified and thought to have roles in carcinogenesis of prostate cancer.
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