2009 Fiscal Year Final Research Report

The application of new bladder cancer marker protein,peripurakin, to urinary cytology and functional analysis.

Research Project

Project/Area Number	20791125
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Jikei University School of Medicine
Principal Investigator	HIROSHI Sasaki Jikei University School of Medicine, 医学部, 助教 (80349589)
Project Period (FY)	2008 – 2009
Keywords	尿器上皮癌 / プロテオミクス / ペリプラキン / マーカー / 尿細胞診
Research Abstract	We found the novel cancer marker protein, periplakin, which disappeared appearance by proteomics analysis of the large molecular weight in bladder cancer. We aimed to establish the noncritical inspection method in urine and examining the PPL appearance in the immunohistochemical analysis. In this study, PPL appearance by the shift epithelial cell in urine has significantly decreased in the cancer patient group compared with the control group. Consequently, it was done by immunostaining of PPL and urinary cytology and using it together the possibility of improving the diagnosis.

(1 results)