2009 Fiscal Year Final Research Report
Investigation of prostate cancer stem cells
| Project/Area Number |
20791126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MIKI Jun Jikei University School of Medicine, 医学部, 助教 (00328361)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 前立腺癌 / 癌幹細胞 |
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| Research Abstract |
Recent evidence supports the cancer stem cell theory, that is, that tumors arise from cells termed cancer stem cells (CSC) or tumor-initiating cells that have the ability of self-renewal and are responsible for maintaining the tumor. We established primary culture cell lines with Lentivirus vector from the specimen of prostatectomy.
We analyzed the characterization of cells from JDCaP which is a novel PCa xenograft moldel. These cells consisted of heterogeneous population, and they may contain the stemness as CSC.These novel in vitro and in vivo models may offer useful tools for the study of the biological features and functional integration of normal and cancer stem cells in prostate.
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