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2009 Fiscal Year Final Research Report

The copy number variation analysis of androgenetic hydatidiform mole with high density SNPs array

Research Project

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Project/Area Number 20791133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionChiba University

Principal Investigator

KAKU Hiroshi  Chiba University, 大学院・医学研究部, 協力研究員 (40456059)

Project Period (FY) 2008 – 2009
Keywords胞状奇胎 / 侵入奇胎 / 雄核発生奇胎 / SNPsアレイ / 遺伝子増幅 / LOH / コピー数変化
Research Abstract

Hydatidiform mole (HM) occurs in about 1 in 400 pregnancies in Japan. There are two different HM entities: androgenetic diploid 'complete' hydatidiform mole (CHM) and triploid 'partial' hydatidiform mole (PHM). CHM has a higher risk of GTN than PHM. It has been estimated that 10-30% of CHM develops GTN. However, we cannot predict which cases develop to gestational trophoblastic neoplasia. We applied 8 cases complete moles (CHM) to high density SNPs array of Affymetrix, and analyzed the array data with Affymetrix Genotyping Console and Microsoft Excel. 1) Homozygous CHM assessed with STR polymorphism analysis were confirmed the homozygosity in whole genome level. 2) We found specific regions in CHM. 3) We found two GTN specific region in chromosome 2 and 22.

  • Research Products

    (7 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles2010

    • Author(s)
      Baasanjav B, Usui H, Kihara M, Kaku H, Nakada E, Tate S, Mitsuhashi A, Matsui H, Shozu M.
    • Journal Title

      Hum Reprod 25

      Pages: 1182-1191

    • Peer Reviewed
  • [Journal Article] 臨床的癒着胎盤の待機療法産婦人科の実際2009

    • Author(s)
      加来博志, 尾本暁子, 生水真紀夫
    • Journal Title

      58

      Pages: 2035-2041

  • [Presentation] 出生前羊水染色体検査にてcomplete trisomy 9と診断されたtrisomy 9 mosaicismの1例2009

    • Author(s)
      田中宏一, 尾本暁子, 鶴岡信栄, 尾崎江都子, 加来博志, 長田久夫, 生水真紀夫
    • Organizer
      第45回日本周産期・新生児医学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-07-14
  • [Presentation] 22q11. 2 deletion症候群合併妊娠の1例2009

    • Author(s)
      長田久夫, 尾本暁子, 尾崎江都子, 加来博志, 鶴岡信栄, 田中宏一, 生水真紀夫
    • Organizer
      第45回日本周産期・新生児医学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-07-14
  • [Presentation] 雄核発生胞状奇胎および絨毛癌培養細胞におけるKvDMRのメチル化状態の解析2009

    • Author(s)
      碓井宏和, 木原真紀, 中田恵美里, 鶴岡信栄, 加来博志, 平敷好一郎, 楯真一, 加藤一喜, 田中宏一, 三橋暁, 松井英雄, 生水真紀夫
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-04
  • [Presentation] 癒着胎盤症例に対する子宮動脈塞栓術を用いた待機的治療の有用性2008

    • Author(s)
      加来博志, ら
    • Organizer
      第60回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-12
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/gyne/index.html

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Published: 2011-06-18   Modified: 2016-04-21  

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