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2010 Fiscal Year Final Research Report

The basic study of the "reprogramming therapy of cancer using the cytosol of oocytes and ES cells.

Research Project

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Project/Area Number 20791140
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Yamanashi

Principal Investigator

FUKASAWA Hiroko  University of Yamanashi, 大学院・医学工学総合研究部, 助教 (60362068)

Project Period (FY) 2008 – 2010
Keywords癌 / 体細胞核移植 / クローン胚 / ES細胞 / ntES細胞
Research Abstract

Although the rate of development of cloned embryos to the blastocyst stage using the treated oocytes was lower than that obtained using fresh oocytes, three live pups were delivered after embryo transfer into pseudopregnant females (0.4% of the oocytes used). Thus, although cryopreservation reduces the potential of oocytes, these cells retain the ability to support the full-term development of cloned embryos.

  • Research Products

    (8 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Generation of healthy cloned mice using enucleated eggs preserved oocytes.2011

    • Author(s)
      Hirata S, Fukasawa H, Wakayama S, Wakayama T, Hoshi K
    • Journal Title

      Cell Reprogram 13(1)

      Pages: 7-11

    • Peer Reviewed
  • [Journal Article] Novel alpha fetoprotein-V mRNA isoform in human.2009

    • Author(s)
      Tagaya H, Fukasawa H, Shoda T, Hirata S, Hoshi K
    • Journal Title

      Reprod Sci 16(8)

      Pages: 794-801

    • Peer Reviewed
  • [Journal Article] 未受精卵の細胞質に凍結が及ぼす影響-凍結除核未受精卵を用いた体細胞クローン胚による検討.2008

    • Author(s)
      深澤宏子, 多賀谷光, 正田朋子, 笠井剛, 平田修司, 星和彦
    • Journal Title

      日本生殖医学会雑誌(シンポジウム) 53(4),99(223)

  • [Journal Article] Effects of sirtinol on early development of the cloned murine embryo.2008

    • Author(s)
      Hirata S, Fukasawa H, Tagaya H, Shoda T, Wakayama T, Hoshi K
    • Journal Title

      Yamanashi Med J 23(4)

      Pages: 97-107

    • Peer Reviewed
  • [Presentation] Spindle replacement of oocyte by metaphase II spindle injection (MESI).2010

    • Author(s)
      Fukasawa H, Fujie M, Mabuchi T, Hirata S
    • Organizer
      The 7th Conference of Asian Society for Mitochondrial Rearch and Medicin and The 10th Conference of Japanese Society of Mitochondrial Rearch and Medicin.
    • Place of Presentation
      Fukuoka
    • Year and Date
      20101200
  • [Presentation] MESI法を用いた1-day-old 卵の紡錘体ならびに細胞質の機能の検討2010

    • Author(s)
      深澤宏子, 藤江道子, 平田修司
    • Organizer
      第55 回日本生殖医学会学術講演会
    • Place of Presentation
      徳島
    • Year and Date
      20101100
  • [Presentation] 未受精卵の核および細胞質に凍結-融解が与える影響2010

    • Author(s)
      深澤宏子, 藤江道子, 平田修司, 星和彦
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20100400
  • [Presentation] 未受精卵の細胞質に凍結が及ぼす影響-凍結除核未受精卵を用いた体細胞クローン胚による検討2008

    • Author(s)
      深澤宏子, 多賀谷光, 正田朋子, 笠井剛,平田修司, 星和彦
    • Organizer
      第53 回日本生殖医学会学術講演会・総会
    • Place of Presentation
      神戸(シンポジウム)
    • Year and Date
      20081023-20081025

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Published: 2012-02-13   Modified: 2016-04-21  

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