2010 Fiscal Year Final Research Report
The role of genetic polymorphisms in polycystic ovary syndrome
| Project/Area Number |
20791154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
BABA Tsuyoshi Sapporo Medical University, 医学部, 講師 (60404654)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 多嚢胞性卵巣症候群 / 遺伝子多型 / インスリン抵抗性 / アディポサイトカイン / アンドロゲン |
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| Research Abstract |
We revealed that the SNPs IRS-1 Gly972Arg and RETN-420 C/G are predisposing factors in PCOS. PCOS patients who have RETN-420 homozygous variant genotype showed significantly higher BMI, higher fasting serum insulin levels, and lower serum adiponectin levels.
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[Journal Article] The contributions of resistin andadiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population.2009
Author(s)
Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T.
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Journal Title
Gynecol Endocrinol. 25
Pages: 498-503
Peer Reviewed
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