2009 Fiscal Year Final Research Report

Analysis of trmorigenesis and drug-resistance of ovarian/endometrial cancer due to imbalance of activin and inhibin.

Research Project

Project/Area Number	20791157
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Wakayama Medical University
Principal Investigator	MABUCHI Yasushi Wakayama Medical University, 医学部, 助教 (80382357)
Project Period (FY)	2008 – 2009
Keywords	アクチビン・インヒビン / 卵巣癌
Research Abstract	No immunostaining for the a-subunit of inhibin was observed in ovarian endometriosis and the normal endometrium. Positive immunostaining for the βA-subunit of inhibin, activin A, activin receptors type IA, type IB, type IIA, type IIB, Smad2, Smad3 and Smad4 was observed in ovarian endometriosis and the normal endometrium. These results suggest that activin A, but not inhibins, might be produced by ovarian endometriosis and the normal endometrium, and that the activin signal transduction system might exist in both ovarian endometriosis and the normal endometrium.

(1 results)