2010 Fiscal Year Final Research Report
Cytokine Gene Expression Signature in Ovarian Cancer
| Project/Area Number |
20791170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YANAIAHARA Nozomu Jikei University School of Medicine, 医学部, 助教 (20349624)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
Host defense against tumors are controlled by several immunological mediators including cytokines that play an important role in host-tumor immune system conflict. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical association with ovarian cancer development and /or progression. We found that a cytokine gene expression signature of ovarian cancer could distinguish the histological subtypes and prognosis. A unique expression pattern found in ovarian clear cell adenocarcinoma might be involved in the pathogenesis of this subtype of ovarian cancer.
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