2009 Fiscal Year Final Research Report

Development of innovative cancer immunotherapy on the basis of release from immune evasion in cervical cancer

Research Project

Project/Area Number	20791173
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Kurume University
Principal Investigator	KAWANO Kouichiro Kurume University, 医学部, 助教 (10320160)
Project Period (FY)	2008 – 2009
Keywords	婦人科腫瘍学 / 腫瘍免疫学
Research Abstract	We proposed an innovative strategy of cancer immunotherapy which not only activated the immune response but released from immune evasion in cervical cancer. In this study, infiltration of cytotoxic T lymphocytes (CTL) which had an important role for an elimination of tumor indicated a good prognosis. On the contrary, expression of pSTAT3 which affect an immune evasion associated with a poor prognosis. Although correlation between infiltration of CTL and the expression of pSTAT3 was not observed in this study, we verified that pSTAT3 up-regulated the production of the molecule which regress immune response such as VEGF and TGF-β in cervical cancer cell line. We expect the development of this innovative strategy for cancer immunotherapy by further investigation.