2009 Fiscal Year Final Research Report
The maintenance of the Japanese cedar specific IgE antibody secreting cells
| Project/Area Number |
20791180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
INAMINE Ayako Chiba University, 大学院・医学研究院, 特任研究員(GーCOE) (70466720)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 鼻科学 |
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| Research Abstract |
Seasonal allergy (such as Japanese cedar pollinosis), the half-life of serum IgE is only about 12 hours, however, production of pollen specific IgE Ab has been persistent in the absent season of allergen. Thus, IgE+ PCs as memory play an important role in the progression of allergic inflammation. However, the establishment of IgE immunological memory is still poorly understood. In this study, we investigate the mechanism of IgE Ab production for a long period. Thus, we have demonstrated that Long-lived IgE+ PC is clinical interest as new target for immunotherapy in Allergic diseases.
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