Elucidation of central olfactory system using functional MRI and Near-infrared spectroscopy(NIRS)

2010 Fiscal Year Final Research Report

• Project/Area Number: 20791192
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kobe University
• Principal Investigator: DOI Kiyoshi Kobe University, 大学院・医学研究科, 助教 (00379380)
• Project Period (FY): 2008 – 2010
• Keywords: fMRI / 近赤外線分光法 / 嗅覚中枢

Research Abstract

Our findings demonstrate that functional MRI (fMRI) combined with a questionnaire and Near-infrared spectroscopy (NIRS) are a useful method for studying the neuroanatomy of olfaction.

Research Products

• [Journal Article] 再生能力を活用した嗅覚障害治療の展開嗅覚障害モデルにおける再生機構の解明 (2010)
  • Author(s): 土井清司
  • Journal Title: 日本鼻科学会誌 49(1) Pages: 67-69
• [Journal Article] メチマゾール投与嗅神経細胞障害モデルにおける嗅球内遺伝子発現の検討 (2010)
  • Author(s): 浦長瀬昌弘, 土井清司, 丹生健一
  • Journal Title: 頭頸部自律神経 24 Pages: 37-39
• [Journal Article] 嗅覚臨床研究の進歩嗅神経細胞の再生研究 (2009)
  • Author(s): 土井清司
  • Journal Title: 日本味と匂学会誌 16(1) Pages: 25-30
• [Journal Article] Functional MRI of regional brain responses to 'pleasant' and 'npleasant' odors. (2009)
  • Author(s): Katata K, Sakai N, Doi.K, Kawamitsu K.
  • Journal Title: Acta Oto-Laryngologica 562 Pages: 85-90
  • Peer Reviewed
• [Journal Article] 感覚器の再生医療 嗅覚の再生医療嗅上皮の再生に向けて (2008)
  • Author(s): Fujii M, Sugimura K, Nibu K.
  • Journal Title: 医学のあゆみ 226(11) Pages: 991-995
• [Journal Article] 鼻副鼻腔の組織修復嗅神経細胞の再生 (2008)
  • Author(s): 土井清司
  • Journal Title: 日本鼻科学会誌 47(1) Pages: 68-69
• [Journal Article] Near-Infrared Spectroscopy of Orbitofrontal Cortex during Odorant Stimulation.
  • Author(s): Kokan N, Sakai N, Doi K, Fujio H, Hasegawa S, Tanimoto H, Nibu K.
  • Journal Title: American journal of Rhinology & Allergy in press
  • Peer Reviewed
• [Presentation] 嗅覚同定能力研究用カードキット(オープンエッセンス:OE)を用いた臨床研究 (2010)
  • Author(s): 藤尾久美、土井清司、丹生健一
  • Organizer: 第49回日本鼻科学会
  • Place of Presentation: 札幌
  • Year and Date: 20100826-20100828
• [Presentation] 嗅覚同定能カードキット(オープンエッセンス)を用いた嗅覚検査 (2010)
  • Author(s): 藤尾久美、谷本均、長谷川信吾、土井清司、丹生健一
  • Organizer: 第111回日本耳鼻咽喉科学会
  • Place of Presentation: 仙台
  • Year and Date: 20100520-20100522
• [Presentation] PhD. Near-Infrared Spectroscopy of Orbitofrontal Cortex in Odorant (2009)
  • Author(s): Norio Kokan MD, Asami Miyazaki PhD, Hitoshi Tanimoto MD, PhD1, Kumi Fujio MD, PhD, Kiyoshi Doi MD, PhD, Nobuyuki Sakai PhD, Ken-ichi Nibu MD.
  • Organizer: the Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery
  • Place of Presentation: San Diego CA, USA
  • Year and Date: 20091004-20091008
• [Presentation] Functional MRIを用いた快・不快臭い刺激による脳局在反応に関する研究 (2009)
  • Author(s): 堅田敬太、坂井信之、土井清司、丹生健一
  • Organizer: 第48回日本鼻科学会
  • Place of Presentation: 島根
  • Year and Date: 20091002-20091003
• [Remarks] ホームページ等