2009 Fiscal Year Final Research Report
Bral2 is essential for the maintenance of the extracellular microenvironment for the synaptic transmission in the auditory system.
| Project/Area Number |
20791195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
BEKKU Yoko Okayama University, 医学部, 技術専門職員 (60397875)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 神経科学 / 聴覚伝導路 / 細胞外マトリックス / 神経細胞周囲網 / プロテオグリカン |
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| Research Abstract |
There are two types of cells in the brain ; the neuronal cell and glial cell. Extracellular matrix (ECM), such as hyaluronan and proteoglycan, exists in extracellular region of these cells. There are two dense organized ECM in the brain, one is in the perineuronal net (PNN) and other is at the node of Ranvier. The PNN is a mesh like structure surrounding the neuronal cell. Bral2 forms ECM complex with hyaluronan and proteoglycan, and is localized in the PNN of the auditory system. In this study, it is strongly suggested that Brals play key roles in the ECM assembly and the complex is essential for the neuronal activity through the analysis of Bral - deficient mice
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