2010 Fiscal Year Final Research Report
Whether insulin can act as a neurotrophic factor in olfactory sensation
| Project/Area Number |
20791205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
SATOH Shinya University of Miyazaki, 医学部, 助教 (50468047)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 嗅覚 / インスリン受容体 / シグナル伝達 |
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| Research Abstract |
We established the expression of insulin receptor in the olfactory mucosa by immunostaining method.
The calcineurin inhibition decreased specifically IRS-2 protein level by 50% in cultured bovine adrenal chromaffin cells, without changing IRS-2 mRNA level, and insulin receptor, insulin-like growth factor-I receptor, IRS-1, PI3K/PDK-1/Akt/GSK-3β and ERK1/ERK2 protein levels.
Additionally, we examined olfactory sensation of persons who had the long term exposure of arsenicum. The impaired sense of small was 51%, and the olfactory anesthesia was 22%.
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[Journal Article] Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.2009
Author(s)
Yanagita T,Maruta T,Nemoto T,Uezono Y,Matsuo K,Satoh S, Yoshikawa N, Kanai T, Kobayashi H, Wada A
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Journal Title
Neuropharmacology 57(3)
Pages: 311-321
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