2009 Fiscal Year Final Research Report
The role of dendritic cell-activating factor TSLP in allergic rhinitis
| Project/Area Number |
20791207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAMEKURA Ryuta Sapporo Medical University, 医学部, 研究員 (70404697)
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| Research Collaborator |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
GO Mitsuru 札幌医科大学, 医学部, 講師 (80448604)
TAKANO Kenichi 札幌医科大学, 医学部, 助教 (70404689)
SAWADA Norimasa 札幌医科大学, 医学部, 教授 (30154149)
KOJIMA Takashi 札幌医科大学, 医学部, 准教授 (30260764)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アレルギー / 病理学 / タイト結合 / 樹状細胞 / TSLP / 鼻粘膜 |
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| Research Abstract |
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell (DC)-mediated T helper 2-type inflammatory responses. TSLP is a master molecule for allergic inflammation such as that in asthma and atopic dermatitis. In the present study, we first found high expression of TSLP in the epithelium of allergic rhinitis with recruitment and infiltration of DCs. In human nasal epithelial cells in vitro TSLP was significantly induced by treatment with the proinflammatory cytokines and a Toll-like receptor ligand. Treatment with TSLP also enhanced the barrier function of tight junctions of human nasal epithelial cells in vitro and mouse DC line XS52 together with an increase of tight junction proteins.
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[Journal Article] Kamekura RThymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
Author(s)
Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
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Journal Title
Histochem Cell Biol 133(3)
Pages: 339-348
Peer Reviewed
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[Journal Article] Kamekura RPPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.2010
Author(s)
Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Masaki T, Murata M, Tanaka S, Fuchimoto J, Himi T, Sawada N
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Journal Title
Pharmacol Res 61(6)
Pages: 489-498
Peer Reviewed
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[Journal Article] Kamekura RThymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.2009
Author(s)
Kojima T, Koizumi JI, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
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Journal Title
Cell Tissue Res 338(2)
Pages: 283-293
Peer Reviewed
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[Journal Article] Kamekura RInduction of JAM-A during differentiation of human THP-1 dendritic cells.2009
Author(s)
Ogasawara N, Kojima T, Go M, Fuchimoto J, Koizumi JI, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
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Journal Title
Biochem Biophys Res Commun 389(3)
Pages: 543-549
Peer Reviewed
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[Journal Article] ヒト鼻粘膜の機能解析から見えてくること2009
Author(s)
氷見徹夫, 郷充, 近藤敦, 高野賢一, 正木智之, 小泉純一, 亀倉隆太, 大國毅, 小笠原徳子, 小島隆, 澤田典均
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Journal Title
Peer Reviewed
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[Journal Article] Expression of thymic stromal lymphopoietin (TSLP) in allergic rhinitis: Induction of tight junction proteins in nasal epithelial cells and dendritic cells by epithelial-derived TSLP.2008
Author(s)
Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J,, Kojima T, Koizumi J, Ogasawara N, Kurose M, Takano K, Go M, Himi T, Sawada N
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Journal Title
Inflammation and Regeneration 28(3)
Pages: 160-165
Peer Reviewed
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[Journal Article] Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation.2008
Author(s)
郷充, 小島隆,, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N
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Journal Title
Mol Pharmacol 74(2)
Pages: 432-442
Peer Reviewed
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