2009 Fiscal Year Final Research Report
Study on intractable otitis media caused by Nontypeable Haemophilus influenza (NTHi) biofilm formation
| Project/Area Number |
20791219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IKEDA Yorihiko Wakayama Medical University, 医学部, 助教 (20423949)
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| Project Period (FY) |
2008 – 2009
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| Keywords | バイオフィルム / 急性中耳炎 / 難治化 |
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| Research Abstract |
Nontypeable Haemophilus influenza (NTHi) has been shown to form biofilm in vivo. The biofilm is defined as a group of bacteria growing as a community in a self- produced polymeric matrix. Several studies show that the ability to form biolilms contributes the persistence of acute otitis media caused by NTHi. The biofilm formations and adherence of NTHi were evaluated by a 96-well pin-replicator assay with a confocal laser scanning microscopy. Bacteria in biofilms were highly resistant to antibiotics.
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