2009 Fiscal Year Final Research Report
Elucidation of inner ear inflammation and basic research of therapeutic strategy for hearing impairment with a blockade of interleukin 6
| Project/Area Number |
20791226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
若林 健一郎 Keio University, 北里研究所病院, 研究員 (40348743)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 難聴治療 / マクロファージ / インターロイキン6 / 炎症反応 / 聴力の改善 |
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| Research Abstract |
For clinical application of hearing loss therapy noise-exposed mice were treated with MR16-1 and evaluated. Improved hearing was noted in noise-exposed mice treated with MR16-1. Histological analysis revealed the decrease in spiral ganglion neurons was ameliorated in the MR16-1-treated group. A remarkable reduction of activated cochlear macrophages in spiral ganglions compared to the control group was observed when treated with MR16-1.
Thus, MR16-1 had protective effects both functionally and pathologically for the noise-damaged cochlea. IL-6 blockade would be a feasible novel therapeutic strategy for hearing loss.
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