2010 Fiscal Year Final Research Report
Expression of Treg and Th17 Lymphocyte Subsets in Eosinophilic Chronic Rhinosinusitis
| Project/Area Number |
20791230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ASAKA Daiya Jikei University School of Medicine, 医学部, 助教 (20317928)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫学 / 好酸球性副鼻腔炎 / Treg / Th17 |
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| Research Abstract |
The clinical feature of eosinophilic chronic rhinosinusitis is intense eosinophilic inflammation in nasal mucosa. The pathophysiology of eosinophilic chronic rhinosinusitis is poorly understood. We thought that unbalance of Th subsets is underlying in pahophisiolosy of eosinophilic chronic rhinosinusitis. The expression of IL-4(+)CD4(+)T cell and IFN-γ(+)CD4(+) T cell in eosinophilic chronic rhinosinusitis were up-regulated in both nasal mucosa and PBMC compare to chronic rhinosinusitis. These result suggest that hyperimmunoreactivity to pathogen may contribute to pathgenesis of eosinophilic chronic rhinosinusitis.
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