2009 Fiscal Year Final Research Report
Hearing mechanism of melanocyte in inner ear
| Project/Area Number |
20791232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chubu University |
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Principal Investigator |
IDA Michiru Chubu University, 生命健康科学研究所, 助教 (80393148)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 内耳 / 難聴 / 色素細胞 / Waardenburg症候群 / 遺伝子改変マウス |
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| Research Abstract |
Waardenburg syndrome, an auditory-pigmentary syndrome, is caused by abnormal differentiation in melanocyte-related gene such as endothelin receptor B (Ednrb). In this study, the aim is an elucidation of hearing loss with pigmentation disorder and its therapeutic development. Ednrb-deficient mice (Ednrb-KO) were deafness and had a defect of melanocyte in inner ear and decrease of spiral ganglion cells. The hearing losses with neurodegeneration of spiral ganglion cells were improved by introducing an Ednrb transgene under control of the dopamine beta-hydroxylase promoter.
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[Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease.2010
Author(s)
Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M.
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Journal Title
Proc Natl Acad Sci U S A. 20;107(29)(Epub)
Pages: 13051-13056
Peer Reviewed
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