2010 Fiscal Year Final Research Report
How YB-1 expression of laryngeal carcinoma influence infiltration, metastasis and resistance for antineoplastic?
| Project/Area Number |
20791237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kurume University |
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Principal Investigator |
MIHASHI Hiroyuki Kurume University, 医学部, 助教 (10441643)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 耳鼻咽喉科学 |
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| Research Abstract |
In the laryngeal cancer, YB-1 expression in the nuclear was not prognostic marker and correlative to infiltration and metastasis. But in the salivary gland cancer, YB-1 expression in the nuclear was found in salivary duct carcinoma much more and correlated with lymph node metastasis, distant metastasis, HER2 and hormone receptor. The group of YB-1 expression in the nuclear was worse prognosis than the group of no expression. So we thought YB-1 expression in the salivary gland cancer is the biomarker which influence to tumor proliferation and metastasis.
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