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2009 Fiscal Year Final Research Report

Protective effects of Channelrhodopsin-2 gene transfer on neuronal cell death

Research Project

  • PDF
Project/Area Number 20791241
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

ISAGO Hitomi  Tohoku University, 国際高等研究教育機構, 技術補佐員 (30400451)

Project Period (FY) 2008 – 2009
Keywords眼生理学 / 神経科学 / 生理学 / 免疫組織化学
Research Abstract

We examined whether the transfer of ChR2 gene rescue the death of ganglion cells induced by the photoreceptor degeneration. We could clearly record the visually evoked potentials in both age of the ChR2 transferred-RCS rats though the amplitudes. These data showed that the function of retinal ganglion cells was kept after the photoreceptor degeneration.In the ChR2-expressing retina, the immunoreactivity (IM) of the p65-IM was observed in the retinal ganglion cell layer. It is known that the expression of p65 has a critical role in keeping the neuronal cell activities. These results indicated that the transfer of ChR2 gene could give some protective effect on the cell death of retinal ganglion cells following the photoreceptor degeneration.

  • Research Products

    (7 results)

All 2010 2009 2008 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats.2010

    • Author(s)
      Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E, Tamai M
    • Journal Title

      Experimental Eye Research 90

      Pages: 429-436

    • Peer Reviewed
  • [Journal Article] Channelrhodopsins provide a breakthrough insight into strategies for curing blindness.2009

    • Author(s)
      Tomita H, Sugano E, Isago H, Tamai M.
    • Journal Title

      J. Genet. 88

      Pages: 409-415

  • [Presentation] Properties of recovered visual function in the Channelrhodopsin-2 transferred Royal College of Sugecns Rat.2009

    • Author(s)
      Tomita H. Sugano E. Isago H. Hiroi T. Yawo H. Tamai M.
    • Organizer
      ARVO
    • Place of Presentation
      Florida, USA
    • Year and Date
      20090503-20090507
  • [Presentation] Restore vision using Channelrhodopsin-2: Character of recovered visual responses in Channelrhodopsin-2 Transferred Royal College of Surgeons rats.2009

    • Author(s)
      Tomita H. Sugano E. Isago H. Hiroi T., Tamai M.
    • Organizer
      Asia ARVO
    • Place of Presentation
      Hyderabad, India
    • Year and Date
      20090115-20090118
  • [Presentation] Channelrodopsin-2による遺伝盲ラットの視機能再建-免疫学的検討-2008

    • Author(s)
      菅野江里子, 富田浩史, 砂金ひとみ, 玉井信
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2008-09-07
  • [Presentation] チャネルロドプシン-2遺伝子を導入した老齢と若齢RCSラットの視覚誘発電位の違いについて2008

    • Author(s)
      砂金ひとみ、富田浩史、菅野江里子、廣井照、玉井信
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2008-09-07
  • [Remarks]

    • URL

      http://www.visual-neuroscience.med.tohoku.ac.jp/

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Published: 2011-06-18   Modified: 2016-04-21  

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