2009 Fiscal Year Final Research Report
Chemokines in Aqueous humour before and after IntravitrealTriamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal VeinOcclusion
| Project/Area Number |
20791243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
KUNIKATA Hiroshi Tohoku University, 病院, 講師 (40361092)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ケモカイン / 前房水 / ステロイド / 黄斑浮腫 / 網膜静脈分枝閉塞 / MIP-1β |
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| Research Abstract |
We determined the aqueous humour levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA) in eyes with macular edema associated with a branch retinal vein occlusion (ME-BRVO). At the baseline, MCP-1 and MIP-1a were detected in the aqueous, and MIP-1b was significantly higher in eyes with a ME-BRVO than in controls. One week after IVTA, the foveal thickness (FT) was significantly decreased, and the levels of MCP-1 and MIP-1b were also significantly reduced. The decrease in the FT was correlated with the decrease of only MIP-1b. This indicates that the steroid-dependent ME-BRVO was closely related with the level of MIP-1b.
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