2009 Fiscal Year Final Research Report
A novel molecular paradigm of age-related macular degeneration in view of the social trend in nocturnal: An approach using an animal model
| Project/Area Number |
20791248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OHISHI Kentaro Hamamatsu University School of Medicine, 光量子医学研究センター, 助教 (80345826)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 網膜光障害 / ラット / 系統差 / 時刻差 / アポトーシス |
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| Research Abstract |
Age-related macular degeneration (AMD) is an ocular disease with visual dysfunction and blindness, which might be induced by sunlight exposure for a long time. Recently, our society has been going toward the nocturnal life, the number of people exposed to bright light in the nighttime has been increasing. Such the actual situation may contribute to the increased prevalence of AMD in future. A white light exposure to a rat leads to retinal dysfunction, and depending on the experimental condition, the rat goes blind, which is called as "experimental retinal photic injury model". Using this model, we investigated how risky the nocturnal exposure to blight light is and the mechanism targeted at BMAL1 protein, aiming at looking into the mechanism of the onset of AMD.
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[Journal Article] Novel RDH5 mutation in family with mother having fundus albipunctatus and three children with retinitis pigmentosa.2008
Author(s)
Wang, C., Nakanishi, N., Ohishi, K., Hikoya, A., Koide, K., Sato, M., Nakamura, M., Hotta, Y., Minoshima, S.
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Journal Title
Ophthalmic Genet. 29(1)
Pages: 29-32
Peer Reviewed
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[Journal Article] Matrix- assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina.2008
Author(s)
Hayasaka, T., Goto-Inoue, N., Sugiura, Y., Zaima, N., Nakanishi, H., Ohishi, K., Nakanishi, S., Naito, T., Taguchi, R., Setou, M.
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Journal Title
Rapid Commun. Mass Spectrom. 22(21)
Pages: 3415-26
Peer Reviewed
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[Presentation] Interaction between optineurin and bZIP transcription factor NRL2009
Author(s)
Wang, C., Hosono, K., Ohtsubo, M., Ohishi, K., Nakanishi, N., Hikoya, A., Sato, M., Hotta, Y., Minoshima, S.
Organizer
Association for Research in Vision and Ophthalmology
Place of Presentation
Florida, USA
Year and Date
20090500
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