2009 Fiscal Year Final Research Report
Analysis of molecular mechanisms in endogenous oxidative stress response and inhibition of retinal degeneration
| Project/Area Number |
20791251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Shimane University |
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Principal Investigator |
TANITO Masaki Shimane University, 医学部, 講師 (30284037)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 網膜光傷害 / 酸化ストレス / 網膜変性 / 脂質過酸化 / Nrf-2 |
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| Research Abstract |
Protein expressions were analyzed in retinal samples from dark- and bright light-reared rats by using proteomics techniques. The results suggested that groups of proteins from several functional categories were involved in retinal protection in in vivo. Retinal levels of fatty acid were changed by a combination use of transgenic mice carrying n-3 fatty acid desaturase and modified fatty acid diet. The results of suggested that lower ratio of n6/n3 fatty acid in retina was related to the high susceptibility of retinal damage induced by intense light exposure.
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