2009 Fiscal Year Final Research Report
Normal tension glaucoma model: Characterization of retinal neuron specific BDNF and cfos knockout
| Project/Area Number |
20791257
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Ehime University |
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Principal Investigator |
KOBAYASHI Takeshi Ehime University, 大学院・医学系研究科, 寄附講座助教 (70380285)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 緑内障 / 正常眼圧 / 網膜 / 脳由来神経栄養因子 / cfos / ノックアウトマウス |
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| Research Abstract |
Retinal neuron specific (Brain-derived neurotrophic factor) BDNF and cfos knockout were studied to characterize the phenotypical change in retinal ganglion cells (RGC). In BDNF knockout, RGC gradually decrease from peripheral potion of retina by aging. Reduction ratio of RGC in cfos knockout was higher than that of RGC in BDNF knockout. Neural retina of cfos knockout did not express mBdnf. It suggest cfos is upstream of BDNF and other neuroprotective factor in the mouse retina. For preventing normal tension glaucoma, neuroprotective transcription factor should be analyzed.
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