2009 Fiscal Year Final Research Report

Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization

Research Project

Project/Area Number	20791271
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Keio University
Principal Investigator	KOTO Takashi Keio University, 医学部, 助教 (60464814)
Project Period (FY)	2008 – 2009
Keywords	脈絡膜血管新生 / 加齢黄斑変性 / CD44
Research Abstract	Pathogene si s of chor oidal neov ascular izat ion involve s mac r ophage ac t ivati on. On the other hand, extr ac el lular matr ix, such as hyalur onan, r egulate s mac r ophage s ac cumulat ion. We r eveal ed that the hyalur onan - CD44 signal ing i s invo lved in the generat ion of chor oidal neovascular i zat ion.

(2 results)