2009 Fiscal Year Final Research Report
Search for the mechanism of corneal epithelium stem cell deficiency by bullous keratopathy
| Project/Area Number |
20791275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
UCHINO Yuichi Keio University, 医学部, 助教 (80365337)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 水疱性角膜症 / 角膜上皮幹細胞 / 角膜輪部機能不全 / 幹細胞疲弊 |
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| Research Abstract |
We could create a rabbit model of bullous keratopathy, by removal of the rabbit corneal endothelium, causing a artificial bullous keratopathy. Our result suggested that the bullous keratopathy increased turnover of the corneal epithelium. The long-term bullous keratopathy may produce the corneal epithelial stem cell depletion and limbal dysfunction.
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