2010 Fiscal Year Final Research Report
Study of pathophysiologic significance of ectodomain shedding in the cornea
| Project/Area Number |
20791284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
SAKIMOTO Tohru Nihon University, 医学部, 助教 (20465272)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞外ドメインシェディング / メタロプロテアーゼ / 角膜 |
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| Research Abstract |
Ectodomain shedding is defined as the disintegration and extracellular release of membranous protein on the cell surface. This cellular process plays a role both in the activation and inactivation of the shedding substrate of shedding, and can potentially change functional characteristics of the substrate. In the cornea, we elucidated that ectodomain shedding is mainly activated in corneal epithelium, and soluble form of TNFR1 and IL-6R is produced from corneal epithelium. We speculated that this process plays an indispensable role in corneal wound healing and reducing inflammatory reactions.
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