2009 Fiscal Year Final Research Report
Immunohistochemical study of fatty acid metabolism in Muller cells of the retina.
| Project/Area Number |
20791286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Fujita Health University |
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Principal Investigator |
ATSUZAWA Kimie Fujita Health University, 医学部, 助教 (60387727)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 眼組織化学 |
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| Research Abstract |
The nutrient metabolism of Muller cell of the retina, fatty acid β-oxidation system in particular, was attempted by biological and morphological studies. All the enzymes examined were shown to be present in the retina with the amount of protein and gene expression in the retina being about 1/10 of those in the liver. Electron microscopic immunohistochemistry revealed the enzymes to be localized to the mitochondria of Muller cells. The present results are helpful in elucidating the pathogenesis of retinal pigmentary degeneration in the inborn error of metabolism in fatty acid β-oxdation.
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