2009 Fiscal Year Final Research Report
Induction of corneal endothelial cells from human embryonic stem cells based on the analysis of molecular markers during corneal endothelial development
| Project/Area Number |
20791288
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
UENO Morio The Institute of Physical and Chemical Research, 細胞分化器官発生研究グループ, 客員研究員 (40426531)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 眼発生 / 再生医学 |
|---|
| Research Abstract |
We generated the knock-in mice expressing a green fluorescent protein (GFP) in mesencephalic neural crest cells and their derivatives. The analysis of molecular markers during corneal endothelial development was performed using the knock-in mice. The in vitro induction of corneal endothelium from mouse embryonic stem cells was developed based on the molecular markers to mimic the mouse corneal endothelial development. The protocol to produce corneal endothelium from mouse embryonic stem cells was applied to in vitro induction of corneal endothelium from human embryonic stem cell. This research shed light on the production of the cellular source for the corneal endothelial transplantation.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 緑内障早期診断・早期治療のための疾患マーカーSNPs解析2009
Author(s)
池田陽子, 森和彦, 上野盛夫, 木下茂, 八木知人, 中野正和, 大見奈津江, 田中雅美, 徳田雄市, 不破正博, 大橋沙矢佳, 斉藤直子, 吉井健吾, 田代啓
Organizer
第115回京都眼科学会
Place of Presentation
京都
Year and Date
2009-09-07
-
-
-
-
-
-
-
-
-
-
-
-
